The control of cellular behavior largely relies on genetic engineering, but artificial cells could be designed to control cell processes through chemical communication. Here, the authors develop an artificial cell that is able to translate a chemical message into a signal that can be sensed by E. coli, in order to activate a cellular response that could not have occurred otherwise.
Lentini R., Perez Santero S., Chizzolini F., Cecchi D., Fontana J., Marchioretto M., Del Bianco C., Terrell J.L., Spencer A.C., Martini L., Forlin M., Assfalg M., Dalla Serra M., Bentley W.E. and Mansy S.S.
Integrating artificial with natural cells to translate chemical messages that direct E. coli behaviour
Nature Communications, 5:4012, 2014 – DOI: 10.1038/ncomms5012